Australian Dry Eye

Click here to edit subtitle

News

Phase 2b trial for Aerie dry eye drop begins

Posted on November 16, 2020 at 8:20 AM

 

A phase 2b clinical trial of AR-15512 ophthalmic solution for the treatment of dry eye disease has been initiated, according to a press release from Aerie Pharmaceuticals.

 


COMET-1 is a randomized, double-masked, vehicle-controlled trial investigating the safety and efficacy of AR-15512, a TRPM8 agonist. The trial aims to enroll about 360 patients who will receive AR-15512 0.0014%, AR-15512 0.003% or AR-15512 vehicle, one drop twice daily in each eye for 3 months. Primary endpoints include ocular discomfort and tear production, and patients will be evaluated at days 14, 28 and 84, the release said.

 


“By activating the TRPM8 receptor, AR-15512 may stimulate tear production as well as reduce ocular discomfort through a mild cooling sensation. We anticipate topline results of COMET-1, which is powered as a phase 3, in the third quarter of 2021,” Vicente Anido Jr., PhD, Aerie chairman and CEO, said in the release.


Reference


https://www.healio.com/news/ophthalmology/20201030/phase-2b-trial-for-aerie-dry-eye-drop-begins

Categories: News